Prof. N. Jayathilaka

Prof. (Ms.) N. JayathilakaProfessor

Email Address	:	njayathi@kln.ac.lk
Telephone (Office)	:	+94 (0)11 2 903 256 (ext: 256)
Office Location	:	B1 110/2
Teaching	:	Biochemistry
Office hours available for students.
Google Scholar \| Research Gate

Research Interests:

Evaluation of diagnostic and prognostic molecular markers such as oxidative stress markers and miRNA in endemic infectious diseases like Dengue, Melioidosis and Scrub Typhus.

Evaluate the effect of fatty acid chain length on fatty acid-mediated absorption of small molecules.

Evaluate the in vitro and in vivo effect of antioxidants on oxidative stress induced macromolecular damage to assess the potential as food preservatives.

Eukaryotic transcriptional regulation and epigenetic control of chromosome structure.

Teaching Interests:

Awards

Selected Recent Research Publications:

Research Articles

Karunasiri A N; Senanayake C M; Hapugaswatta H; Jayathilaka N; Seneviratne K N. (2020). P rotective Effect of Coconut Oil Meal Phenolic Antioxidants against Macromolecular Damage: In Vitro and In Vivo Study. Journal of Chemistry DOI: 10.1155/2020/3503165
Karunasiri A N, Gunawardane M, Senanayake C M, Jayathilaka N, Seneviratne K N, (2020) Antioxidant and Nutritional Properties of Domestic and Commercial Coconut Milk Preparations, International Journal of Food Science, Vol 2020, doi.org/10.1155/2020/3489605
Hapugaswatta, H., Amarasena, P., Premaratna, R., Seneviratne, K. N., Jayathilaka, N. (2020). Differential expression of microRNA, miR150 and enhancer of zeste homolog 2 (EZH2) in peripheral blood cells as early markers of severe forms of Dengue, Journal of Biomedical Science. 27:25, https://doi.org/10.1186/s12929-020-0620-z
Senanayake C M, Algama C H, Wimalasekara R L, Weerakoon W. N. M. T. D. N., Jayathilaka N, Seneviratne K N (2019) Improvement of Oxidative Stability and Microbial Shelf Life of Vanilla Cake by Coconut Oil Meal and Sesame Oil Meal Phenolic Extracts. Journal of Food Quality. Article ID 1263629, Volume 2019

Senanayake C M, Hapugaswatte H, Jayathilaka N, Seneviratne K N (2018) Phenolic extracts of the leaves of Psidium guineense Sw. improve the shelf life of sunflower oil and baked cake and antioxidant status of Wistar rats. Journal of Food Biochemistry. https://doi.org/10.1111/jfbc.12632

Prasadani WC, Senanayake C M, Jayathilaka N, Ekanayake S, Seneviratne KN (2017), Effect of three edible oils on the intestinal absorption of caffeic acid: An in vivo and in vitro study.PloS one. Vol 12, Issue 6, e0179292.

Krishnananthasivam S, JayathilakaN, Sathkumara H D, Corea E, Natesan M, De Silva A D (2017) Host gene expression analysis in Sri Lankan melioidosis patients. PLOS Neglected Tropical Diseases. 0005643.

Wei J, Joshi S, Speransky S, Crowley C, Jayathilaka N, Lei X, Wu Y, Gai D, Jain S, Hoosien M, Gao Y, Chen L, Bishopric N H. (2017) Reversal of pathological cardiac hypertrophy via the MEF2-coregulator interface. JCI insight. Vol 2, Issue 17.

Nadeeshani R, Wijayaratna U N, Prasadani W C, Ekanayake S, Seneviratne K N, Jayathilaka N^* (2015) Comparison of the Basic Nutritional Characteristics of the First Extract and Second Extract of Coconut Milk, International Journal of Innovative Research in Science, Engineering and Technology. Vol 4, Issue 10, pp. 9516 – 9521.

Jayathilaka N^*, Weeraratne K S, Buwaneka P A, Dilhani G R S (2015) Epigenetic Modifications in Human Disease, Kalyani Journal of the University of Kelaniya, 2015 Vol. 30, pp. 79

Jayathilaka N, Han A, Gaffney KJ, Dey R, Jarusiewicz JA, Noridomi K, Philips MA, Lei X, He J, Ye J, Gao T, Petasis NA, Chen L, Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2, Nucleic Acids Res., 40(12) (2012) 5378-88.

Kalhor R, Tjong H, Jayathilaka N, Alber F, Chen L, Genome architechtures revealed by tethered chromosome conformation capture and population-based modeling, Nature Biotechnol., 30(1) (2011) 90-8.

Wu Y, Dey R, Han A, Jayathilaka N, Philips M, Ye J, Chen L, Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment, J Mol Biol., 397(2) (2010) 520-33.

Li Z, Luo RT, Mi S, Sun M, Chen P, Bao J, Neilly MB, Jayathilaka N, Johnson DS, Wang L, Lavau C, Zhang Y, Tseng C, Zhang X, Wang J, Yu J, Yang H, Wang SM, Rowley JD, Chen J, Thirman MJ, Consistent deregulation of gene expression between human and murine MLL rearrangement leukemia’s, Cancer Res., 69(3) (2009) 1109-16.

Gerr HD, Nassin ML, Davis EM, Jayathilaka N, Neilly ME, Schlegelberger B, Zhang Y, Rowley JD, Cytogenetic and molecular study of the PRDX4 gene in a t(X;18)(p22;q23): a cautionary tale, Cancer Genet Cytogenet., 176(2) (2007) 131-6.

Lee S, Chen J, Zhou G, Shi RZ, Bouffard GG, Kocherginsky M, Ge X, Sun M, Jayathilaka N, Kim YC, Emmanuel N, Bohlander SK, Minden M, Kline J, Ozer O, Larson RA, LeBeau MM, Green ED, Trent J, Karrison T, Liu PP, Wang SM, Rowley JD, Gene expression profiles in acute myeloid leukemia with common translocations using SAGE, Proc Natl Acad Sci U S A, 103(4) (2006) 1030-5.

Lee S, Johnson D, Dunbar K, Dong H, Ge X, Kim YC, Wing C, Jayathilaka N, Emmanuel N, Zhou CQ, Gerber HL, Tseng CC, Wang SM. 2.45GHz radiofrequency fields alter gene expression in cultured human cells, FEBS Lett., 579(21) (2005) 4829-36.

Zhang Y, Zeleznik-Le N, Emmanuel N, Jayathilaka N, Chen J, Strissel P, Strick R, Li L, Neilly MB, Taki T, Hayashi Y, Kaneko Y, Schlegelberger B, Rowley JD, Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16), Genes Chromosomes Cancer, 41(3) (2004) 257-65.

ka N, Chen J, Strissel P, Strick R, Li L, Neilly MB, Taki T, Hayashi Y, Kaneko Y, Schlegelberger B, Rowley JD,Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16),Genes Chromosomes Cancer,41(3) (2004) 257-65.

Books

Seneviratne K N, Jayathilaka N (2016) Coconut Oil: Chemistry and Nutrition, Lakva Publishers, Battaramulla, Sri Lanka.

Books Chapters

Seneviratne K N, Jayathilaka N (2015) Corn and Coconut Oil: Antioxidant Properties, Uses and Health Benefits, Chapter 6, pp. 103-130, Production Methods and Coconut Oil Quality, Nova Science Publishers, Inc.

Patents

Small Molecule modulators of epigenetic regulation and their therapeutic applications (wo/2010/054126).
- The invention pertains to methods and compositions for modulating the function of transcription factors that recruit epigenetic regulators to specific DNA promoters. The targeted transcription factors include myocyte enhancing factor and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabinland the therapeutic applications thereof.

A method for improving the shelf life and oxidative stability of edible oils, bakery products and other commercial human and animal food products using coconut oil cake (poonac) extracts (patent pending; submitted in 2017)

A Method for improving the shelf life and oxidative stability of bakery products using Psidium guineense Sw. leaf extract. (Sri Lanka patent No. 19796, 2018)